Karsten Borgwardt

Karsten Borgwardt

Karsten Borgwardt (born 1980) is a German computer scientist and biologist specializing in machine learning and computational biology. Since February 2023, he has been a director at the Max Planck Institute of Biochemistry in Martinsried, Germany, where he leads the Department of Machine Learning and Systems Biology. == Education and career == Borgwardt was born in Kaiserslautern. He obtained a Diplom (equivalent to a master’s degree) in computer science from LMU Munich in 2004 and a Master of Science in biology from the University of Oxford in 2003. In 2007, he obtained his PhD from LMU Munich in computer science. Following a postdoctoral position at the University of Cambridge, he became a research group leader for machine learning and computational biology at the Max Planck Institute for Biological Cybernetics and the former Max Planck Institute for Developmental Biology in Tübingen in 2008. In 2011, Borgwardt was appointed professor of data mining in the life sciences at the University of Tübingen. In 2014, he joined ETH Zurich as an associate professor in the Department of Biosystems Science and Engineering (D-BSSE) and was promoted to full professor in 2017. During his tenure at ETH Zurich, he coordinated significant research programs, including two Marie Curie Innovative Training Networks and the Personalized Swiss Sepsis Study, focusing on the prediction of sepsis using machine learning. In 2023, he was appointed as Scientific Member of the Max Planck Society and as Director at the Max Planck Institute of Biochemistry in Martinsried. == Research contributions == Borgwardt’s research integrates big data analysis with biomedical research. He develops novel machine learning algorithms to detect patterns and statistical dependencies in large biological and medical datasets. His work aims to enable the automatic generation of new knowledge from big data and to understand the relationship between the function of biological systems and their molecular properties, which is fundamental for personalized medicine. == Awards and honors == During his studies, he was a scholar of the Stiftung Maximilianeum, and the Bavarian Foundation for the Promotion of the Gifted. Borgwardt received scholarships from the Studienstiftung des deutschen Volkes in 2002 and 2007. His PhD dissertation received the Heinz Schwärtzel Dissertation Award for Foundations of Computer Science in 2007. As a professor in Tübingen, he was awarded the Alfried-Krupp-Förderpreis for Young Professors in 2013. In 2015, he received an SNSF Starting Grant. In 2014, 2015 and 2016, he was listed in “Top 40 under 40” in Germany rankings selected by Capital magazine. In 2018, Borgwardt was named among “25 individuals who have the potential to shape the next 25 years” by Focus magazine. In 2023, Borgwardt received an honorary professorship from LMU Munich by the Faculty of Chemistry and Pharmacy. Publications from Borgwardt's group have received the Outstanding Student Paper Award in NIPS in 2009, the SIB Graduate Paper Award in 2020 and SIB Remarkable Output Awards in 2020 and 2021 from the Swiss Institute of Bioinformatics (SIB). == Selected publications == Weisfeiler-Lehman Graph Kernels (’‘Journal of Machine Learning Research’’, 2011): Introduced an efficient graph kernel based on the Weisfeiler-Lehman algorithm. “Direct antimicrobial resistance prediction from clinical MALDI-TOF mass spectra using machine learning” (’‘Nature Medicine’’, 2022): showcased the feasibility of predicting antimicrobial resistance from readily collected mass spectrometry data in the hospital. The new method is able to identify antibiotic resistance 24 hours earlier than previous methods.

Local coordinates

Local coordinates are the ones used in a local coordinate system or a local coordinate space. Simple examples: Houses. In order to work in a house construction, the measurements are referred to a control arbitrary point that will allow to check it: stick/sticks on the ground, steel bar, nails... Addresses. Using house numbers to locate a house on a street; the street is a local coordinate system within a larger system composed of city townships, states, countries, postal codes, etc. Local systems exist for convenience. On ancient times, every work was made on relative bases as there was no conception of global systems. Practically, it is better to use local systems for small works as houses, buildings... For most of the applications, it is desired the position of one element relative to one building or location, and in a more local way, relative to one furniture or person. In a regular way, you will not give your position by geographical coordinates rather than "I am 15 meters away of the entry to the building". So it is a pretty common way to locate things. It is possible to bring latitude and longitude for all terrestrial locations, but unless one has a highly precise GPS device or you make astronomical observations, this is impractical. It is much simpler to use a tape, a rope, a chain... The position information (global) should be transformed into a location. Position refers to a numeric or symbolic description within a spatial reference system, whereas location refers to information about surrounding objects and their interrelationships. (Topological space) == Use == In computer graphics and computer animation, local coordinate spaces are also useful for their ability to model independently transformable aspects of geometrical scene graphs. When modeling a car, for example, it is desirable to describe the center of each wheel with respect to the car's coordinate system, but then specify the shape of each wheel in separate local spaces centered about these points. This way, the information describing each wheel can be simply duplicated four times, and independent transformations (e.g., steering rotation) can be similarly effected. Bounding volumes of objects may be described more accurately using extents in the local coordinates, (i.e. an object oriented bounding box, contrasted with the simpler axis aligned bounding box). The trade-off for this flexibility is additional computational cost: the rendering system must access the higher-level coordinate system of the car and combine it with the space of each wheel in order to draw everything in its proper place. Local coordinates also afford digital designers a means around the finite limits of numerical representation. The tread marks on a tire, for example, can be described using millimeters by allowing the whole tire to occupy the entire range of numeric precision available. The larger aspects of the car, such as its frame, might be described in centimeters, and the terrain that the car travels on could be specified in meters. In differential topology, local coordinates on a manifold are defined by means of an atlas of charts. The basic idea behind coordinate charts is that each small patch of a manifold can be endowed with a set of local coordinates. These are collected together into an atlas, and stitched together in such a way that they are self-consistent on the manifold. In Cartography and Maps, the traditional way of works are local datum. With a local datum the land can be mapped on relative small areas as a country. With the need of global systems, the transformations on between datum became a problem, so geodetic datum have been created. More than 150 local datum have been used in the world.

Client honeypot

Honeypots are security devices whose value lie in being probed and compromised. Traditional honeypots are servers (or devices that expose server services) that wait passively to be attacked. Client Honeypots are active security devices in search of malicious servers that attack clients. The client honeypot poses as a client and interacts with the server to examine whether an attack has occurred. Often the focus of client honeypots is on web browsers, but any client that interacts with servers can be part of a client honeypot (for example ftp, email, ssh, etc.). There are several terms that are used to describe client honeypots. Besides client honeypot, which is the generic classification, honeyclient is the other term that is generally used and accepted. However, there is a subtlety here, as "honeyclient" is actually a homograph that could also refer to the first known open source client honeypot implementation (see below), although this should be clear from the context. == Architecture == A client honeypot is composed of three components. The first component, a queuer, is responsible for creating a list of servers for the client to visit. This list can be created, for example, through crawling. The second component is the client itself, which is able to make a requests to servers identified by the queuer. After the interaction with the server has taken place, the third component, an analysis engine, is responsible for determining whether an attack has taken place on the client honeypot. In addition to these components, client honeypots are usually equipped with some sort of containment strategy to prevent successful attacks from spreading beyond the client honeypot. This is usually achieved through the use of firewalls and virtual machine sandboxes. Analogous to traditional server honeypots, client honeypots are mainly classified by their interaction level: high or low; which denotes the level of functional interaction the server can utilize on the client honeypot. In addition to this there are also newly hybrid approaches which denotes the usage of both high and low interaction detection techniques. == High interaction == High interaction client honeypots are fully functional systems comparable to real systems with real clients. As such, no functional limitations (besides the containment strategy) exist on high interaction client honeypots. Attacks on high interaction client honeypots are detected via inspection of the state of the system after a server has been interacted with. The detection of changes to the client honeypot may indicate the occurrence of an attack against that has exploited a vulnerability of the client. An example of such a change is the presence of a new or altered file. High interaction client honeypots are very effective at detecting unknown attacks on clients. However, the tradeoff for this accuracy is a performance hit from the amount of system state that has to be monitored to make an attack assessment. Also, this detection mechanism is prone to various forms of evasion by the exploit. For example, an attack could delay the exploit from immediately triggering (time bombs) or could trigger upon a particular set of conditions or actions (logic bombs). Since no immediate, detectable state change occurred, the client honeypot is likely to incorrectly classify the server as safe even though it did successfully perform its attack on the client. Finally, if the client honeypots are running in virtual machines, then an exploit may try to detect the presence of the virtual environment and cease from triggering or behave differently. === Capture-HPC === Capture [1] is a high interaction client honeypot developed by researchers at Victoria University of Wellington, NZ. Capture differs from existing client honeypots in various ways. First, it is designed to be fast. State changes are being detected using an event based model allowing to react to state changes as they occur. Second, Capture is designed to be scalable. A central Capture server is able to control numerous clients across a network. Third, Capture is supposed to be a framework that allows to utilize different clients. The initial version of Capture supports Internet Explorer, but the current version supports all major browsers (Internet Explorer, Firefox, Opera, Safari) as well as other HTTP aware client applications, such as office applications and media players. === HoneyClient === HoneyClient [2] is a web browser based (IE/FireFox) high interaction client honeypot designed by Kathy Wang in 2004 and subsequently developed at MITRE. It was the first open source client honeypot and is a mix of Perl, C++, and Ruby. HoneyClient is state-based and detects attacks on Windows clients by monitoring files, process events, and registry entries. It has integrated the Capture-HPC real-time integrity checker to perform this detection. HoneyClient also contains a crawler, so it can be seeded with a list of initial URLs from which to start and can then continue to traverse web sites in search of client-side malware. === HoneyMonkey (dead since 2010) === HoneyMonkey [3] is a web browser based (IE) high interaction client honeypot implemented by Microsoft in 2005. It is not available for download. HoneyMonkey is state based and detects attacks on clients by monitoring files, registry, and processes. A unique characteristic of HoneyMonkey is its layered approach to interacting with servers in order to identify zero-day exploits. HoneyMonkey initially crawls the web with a vulnerable configuration. Once an attack has been identified, the server is reexamined with a fully patched configuration. If the attack is still detected, one can conclude that the attack utilizes an exploit for which no patch has been publicly released yet and therefore is quite dangerous. === SHELIA (dead since 2009) === Shelia [4] is a high interaction client honeypot developed by Joan Robert Rocaspana at Vrije Universiteit Amsterdam. It integrates with an email reader and processes each email it receives (URLs & attachments). Depending on the type of URL or attachment received, it opens a different client application (e.g. browser, office application, etc.) It monitors whether executable instructions are executed in data area of memory (which would indicate a buffer overflow exploit has been triggered). With such an approach, SHELIA is not only able to detect exploits, but is able to actually ward off exploits from triggering. === UW Spycrawler === The Spycrawler [5] developed at the University of Washington is yet another browser based (Mozilla) high interaction client honeypot developed by Moshchuk et al. in 2005. This client honeypot is not available for download. The Spycrawler is state based and detects attacks on clients by monitoring files, processes, registry, and browser crashes. Spycrawlers detection mechanism is event based. Further, it increases the passage of time of the virtual machine the Spycrawler is operating in to overcome (or rather reduce the impact of) time bombs. === Web Exploit Finder === WEF [6] is an implementation of an automatic drive-by-download – detection in a virtualized environment, developed by Thomas Müller, Benjamin Mack and Mehmet Arziman, three students from the Hochschule der Medien (HdM), Stuttgart during the summer term in 2006. WEF can be used as an active HoneyNet with a complete virtualization architecture underneath for rollbacks of compromised virtualized machines. == Low interaction == Low interaction client honeypots differ from high interaction client honeypots in that they do not utilize an entire real system, but rather use lightweight or simulated clients to interact with the server. (in the browser world, they are similar to web crawlers). Responses from servers are examined directly to assess whether an attack has taken place. This could be done, for example, by examining the response for the presence of malicious strings. Low interaction client honeypots are easier to deploy and operate than high interaction client honeypots and also perform better. However, they are likely to have a lower detection rate since attacks have to be known to the client honeypot in order for it to detect them; new attacks are likely to go unnoticed. They also suffer from the problem of evasion by exploits, which may be exacerbated due to their simplicity, thus making it easier for an exploit to detect the presence of the client honeypot. === HoneyC === HoneyC [7] is a low interaction client honeypot developed at Victoria University of Wellington by Christian Seifert in 2006. HoneyC is a platform independent open source framework written in Ruby. It currently concentrates driving a web browser simulator to interact with servers. Malicious servers are detected by statically examining the web server's response for malicious strings through the usage of Snort signatures. === Monkey-Spider (dead since 2008) === Monkey-Spider [8] is a low-interaction client honeypot i

T-vertices

T-vertices is a term used in computer graphics to describe a problem that can occur during mesh refinement or mesh simplification. The most common case occurs in naive implementations of continuous level of detail, where a finer-level mesh is "sewn" together with a coarser-level mesh by simply aligning the finer vertices on the edges of the coarse polygons. The result is a continuous mesh, however due to the nature of the z-buffer and certain lighting algorithms such as Gouraud shading, visual artifacts can often be detected. Some modeling algorithms such as subdivision surfaces will fail when a model contains T-vertices.

CPU modes

CPU modes (also called processor modes, CPU states, CPU privilege levels and other names) are operating modes for the central processing unit of most computer architectures that place restrictions on the type and scope of operations that can be performed by instructions being executed by the CPU. For example, this design allows an operating system to run with more privileges than application software by running the operating systems and applications in different modes. Ideally, only highly trusted kernel code is allowed to execute in the unrestricted mode; everything else (including non-supervisory portions of the operating system) runs in a restricted mode and must use a system call (via interrupt) to request the kernel perform on its behalf any operation that could damage or compromise the system, making it impossible for untrusted programs to alter or damage other programs (or the computing system itself). Device drivers are designed to be part of the kernel due to the need for frequent I/O access. Multiple modes can be implemented, e.g. allowing a hypervisor to run multiple operating system supervisors beneath it, which is the basic design of many virtual machine systems available today. == Mode types == The unrestricted mode is often called kernel mode, but many other designations exist (master mode, supervisor mode, privileged mode, etc.). Restricted modes are usually referred to as user modes, but are also known by many other names (slave mode, problem state, etc.). Hypervisor Hypervisor mode is used to support virtualization, allowing the simultaneous operation of multiple operating systems. Kernel and user In kernel mode, the CPU may perform any operation allowed by its architecture; any instruction may be executed, any I/O operation initiated, any area of memory accessed, and so on. In the other CPU modes, certain restrictions on CPU operations are enforced by the hardware. Typically, certain instructions are not permitted (especially those—including I/O operations—that could alter the global state of the machine), some memory areas cannot be accessed, etc. User-mode capabilities of the CPU are typically a subset of those available in kernel mode, but in some cases, such as hardware emulation of non-native architectures, they may be significantly different from those available in standard kernel mode. Some CPU architectures support more modes than those, often with a hierarchy of privileges. These architectures are often said to have ring-based security, wherein the hierarchy of privileges resembles a set of concentric rings, with the kernel mode in the center. Multics hardware was the first significant implementation of ring security, but many other hardware platforms have been designed along similar lines, including the Intel 80286 protected mode, and the IA-64 as well, though it is referred to by a different name in these cases. Mode protection may extend to resources beyond the CPU hardware itself. Hardware registers track the current operating mode of the CPU, but additional virtual-memory registers, page-table entries, and other data may track mode identifiers for other resources. For example, a CPU may be operating in Ring 0 as indicated by a status word in the CPU itself, but every access to memory may additionally be validated against a separate ring number for the virtual-memory segment targeted by the access, and/or against a ring number for the physical page (if any) being targeted. This has been demonstrated with the PSP handheld system. Hardware that meets the Popek and Goldberg virtualization requirements makes writing software to efficiently support a virtual machine much simpler. Such a system can run software that "believes" it is running in supervisor mode, but is actually running in user mode. == Architectures == Several computer systems introduced in the 1960s, such as the IBM System/360, DEC PDP-6/PDP-10, the GE-600/Honeywell 6000 series, and the Burroughs B5000 series and B6500 series, support two CPU modes; a mode that grants full privileges to code running in that mode, and a mode that prevents direct access to input/output devices and some other hardware facilities to code running in that mode. The first mode is referred to by names such as supervisor state (System/360), executive mode (PDP-6/PDP-10), master mode (GE-600 series), control mode (B5000 series), and control state (B6500 series). The second mode is referred to by names such as problem state (System/360), user mode (PDP-6/PDP-10), slave mode (GE-600 series), and normal state (B6500 series); there are multiple non-control modes in the B5000 series. === RISC-V === RISC-V has three main CPU modes: User Mode (U), Supervisor Mode (S), and Machine Mode (M). Virtualization is supported via an orthogonal CSR setting instead of a fourth mode.

List of robotics journals

List of robotics journals includes notable academic and scientific journals that focus on research in the field of robotics and automation. == Journals == Acta Mechanica et Automatica Advanced Robotics Annual Review of Control, Robotics, and Autonomous Systems IEEE Robotics and Automation Letters IEEE Transactions on Robotics IEEE Transactions on Field Robotics The International Journal of Advanced Manufacturing Technology International Journal of Humanoid Robotics International Journal of Robotics Research Journal of Cognitive Engineering and Decision Making Journal of Field Robotics Journal of Intelligent & Robotic Systems Paladyn Robotics and Autonomous Systems Robotics Science Robotics SLAS Technology

List of security assessment tools

This is a list of available software and hardware tools that are designed for or are particularly suited to various kinds of security assessment and security testing. == Operating systems and tool suites == Several operating systems and tool suites provide bundles of tools useful for various types of security assessment. === Operating system distributions === Kali Linux (formerly BackTrack), a penetration-test-focused Linux distribution based on Debian Pentoo, a penetration-test-focused Linux distribution based on Gentoo ParrotOS, a Linux distro focused on penetration testing, forensics, and online anonymity. == Tools ==